Nerves connect with muscles at the neuromuscular junction. These junctions contain receptors that enable the muscle to respond to acetylcholine, a chemical messenger (neurotransmitter) released by the nerve to transmit a nerve impulse across the neuromuscular junction.
What is Neuromuscular Junction Disorder?
Which are neuromuscular junction disorders?
What is Myasthenia Gravis?
Myasthenia gravis is most common neuromuscular disorder which leads to weakness in skeletal muscles. In myasthenia gravis, antibodies (immune proteins) block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction, which prevents the muscle from contracting. These antibodies are produced by the body's own immune system. The thymus is a gland that controls immune function and maybe associated with myasthenia gravis. It most commonly impacts young adult women (under 40) and older men (over 60).
Certain muscles such as those that control eye and eyelid movement, facial expression, chewing, talking, and swallowing are often (but not always) involved in the disorder. The muscles that control breathing and neck and limb movements may also be affected.
What are the symptoms of Myasthenia Gravis?
How is Myasthenia Gravis diagnosed?
How is Myasthenia Gravis treated?